Sunday, June 3, 2007
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Launched to provide a parallel information service connected with _Toward a Bioregional State, the book; this parallel blog is the commentary, your questions and my answers, on technological and material science news from around the world related to the issues of sustainability and unsustainability and how to institutionalize it in particular watersheds anywhere in the world, in a running muse on various issues of concern or inspiration.
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Vitamin K as antidote for poisoning by 4-hydroxcoumarin drugs
Vitamin K is a true antidote for poisoning by 4-hydroxycoumarin anticoagulant drugs (sometimes loosely referred to a coumarins).
These include the pharmaceutical warfarin, and also anticoagulant-mechanism poisons such as bromadiolone, which are commonly found in rodenticides.
4-hydroxycoumarin drugs possess anticoagulatory and rodenticidal properties because they can completely block synthesis of vitamin K in the liver.
Death is usually a result of internal hemorrhage. Treatment usually consists of repeated intravenous doses of vitamin K, followed by doses in pill form for a period of at least two weeks, though possibly up to 2 months, afterwards (in the case of the more potent 4-hydoxycoumarins used as rodenticides).
If caught early, prognosis is good, even when great amounts of the drug or poison are ingested.
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http://en.wikipedia.org/wiki/Vitamin_K
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